上海锐信生物技术有限公司

Shanghai Ruixin Biotechnology Co., Ltd.

HELIOS 间充质干细胞高效营养添加物

牛血清/动物蛋白添加物的缺点：

• 许多已知或未知的病原传染风险

• 异种物质的免疫排斥问题(Sundin, M., et al. No alloantibodies against mesenchymal stromalcells, but presence of anti-fetal calf serum antibodies, after transplantationin allogeneic hematopoietic stem cell recipients. 2007 Haematologica 92,1208–1215., Mackensen, A., et al. (2000). Presence of IgE antibodies to bovineserum albumin in a patient developing anaphylaxis after vaccination with humanpeptide-pulsed dendritic cells. Cancer Immunology, Immunotherapy, Vol.49, No.3,pp.152-156)

• 欧美将立法禁止使用牛血清与动物蛋白添加物于细胞治疗用途。(e.g. DirkStrunk and Dr. Katharina Schallmoser, Technology Offer, Medical University ofGraz, 2008)

• 胎牛血清供应量无法满足市场需求，常有缺货或断货问题

• 批次间不稳定